吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
荫蒂每天被三个男人添小说,一本狠狠色丁香婷婷综合久久
Rabbit Anti-Caspase-10/PE-Cy5 Conjugated antibody (bs-23454R-PE-Cy5)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@xucheq.com
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-23454R-PE-Cy5
英文名稱1 Rabbit Anti-Caspase-10/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標(biāo)記的半胱胺酸蛋白酶-10抗體
別    名 Caspase-10 subunit p23/17; ALPS 2; ALPS2; Apoptosis related cysteine peptidase; Apoptotic protease Mch 4; CASP 10; CASP10; CASP10 protein; Caspase 10 apoptosis related cysteine peptidase; Caspase 10 apoptosis related cysteine protease; Caspase10; FADD Like Ice 2; Fas Associated Death Domain Protein; FAS associated death domain protein interleukin 1B converting enzyme 2; FLICE 2; FLICE2; ICE Like Apoptotic Protease 4; Interleukin 1B Converting Enzyme 2; MCH 4; MCH4.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  細(xì)胞凋亡  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, 
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 22/59kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Caspase-10
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.05M PB, pH 7.5.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Caspases are a family of intracellular proteases that mediate cell death and are the principal effectors of apoptosis. Caspase 10 (Mch4, ICE-LAP4, FLICE2) plays an important role in apoptosis induced by a variety of inducers such as TNF alpha and Anti-Fas antibody. It is a large prodomain caspase classified together with caspases 2, 8, and 9 as a signaling caspase. Four isoforms of caspase 10 (caspase 10a, 10b, 10c, and 10d) having the same prodomain but different mature large and small subdomain, have been described. Caspase 10 contains two death domains (DED) involved in linking to the death effector domain of the adapter protein FADD and recruiting the complex to TNFR1 and Fas. The inactive procaspase 10 is variably expressed in many tissues and cell lines as a cytosolic protein. The mature form of caspase 10 comprises two subunits, p23/p17 (splice isoforms) and p12. Interestingly, a caspase 9- dependent processing of caspase 10 by caspase 6 in cell-free extracts has recently been suggested. Caspase 10 can cleave and activate caspases 3, 4, 6, 7, 8, and 9. This is followed by cleavage of numerous key proteins, including the nuclear protein PARP.

Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.

Subunit:
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 23/17 kDa (p23/17) (depending on the splicing events) and a 12 kDa (p12) subunit (By similarity). Self-associates. Interacts with FADD and CASP8. Found in a Fas signaling complex consisting of FAS, FADD, CASP8 and CASP10.

Tissue Specificity:
Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.

Post-translational modifications:
Cleavage by granzyme B and autocatalytic activity generate the two active subunits.
Phosphorylated upon DNA damage, probably by ATM or ATR.

DISEASE:
Defects in CASP10 are the cause of autoimmune lymphoproliferative syndrome type 2A (ALPS2A) [MIM:603909]. ALPS2 is characterized by abnormal lymphocyte and dendritic cell homeostasis and immune regulatory defects.
Defects in CASP10 are a cause of familial non-Hodgkin lymphoma (NHL) [MIM:605027]. NHL is a cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss.

Similarity:
Belongs to the peptidase C14A family.
Contains 2 DED (death effector) domains.

Database links:

Entrez Gene: 843 Human

Omim: 601762 Human

SwissProt: Q92851 Human

Unigene: 5353 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
浪漫樱花动漫在线观看免费| 欧美黑人添添高潮A片WWW| 欧美激情综合色综合啪啪五月| 欧美熟妇另类久久久久久不卡| 全部孕妇毛片丰满孕妇孕交| 久久久久亚洲精品无码网址| JAPANESEHD熟女熟妇| 国产精品免费无遮挡无码永久视频| 美女高潮黄又色高清视频免费| 人妻丰满熟妇无码区免费| 国产69久久精品成人看| 欧美精品V国产精品V日韩精品| 无码少妇高潮浪潮AV久久| 人妻丰满精品一区二区A片| 欧美虐SM另类残忍视频| 天天干天天日| 狂野欧美性猛交免费视频| 一本大道伊人AV久久综合| 无码人妻少妇伦在线电影| 1000部精品久久久久久久久| 成人免费ā片在线观看| 亚洲AV无码码潮喷在线观看 | 日韩AV无码一区二区三区不卡| 欧美亚洲一区二区三区| 全免费A级毛片免费看| B站禁止转播404入口| 欧美巨大另类极品videosbest| AV电影网站| 小莹乳液汁水停电了还能用吗| 精品人妻无码区二区三区| 高潮VIDEOSSEX潮喷另类| 97久久精品人人澡人人爽| 日本免费一区二区三区高清视频| 草色噜噜噜AV在线观看香蕉| 妺妺窝人体色WWW看美女| 天堂资源最新在线| 天天躁日日躁狠狠躁AV麻豆| 精品一区二区三区在线观看| AV免费网站在线观看| 无人在线观看完整免费版视频| 波多野结衣中文字幕一区二区三区|